24 Louisville Cardinals vs Clemson Tigers
Saturday, February 28, 2026
Matchup Analysis
This NCAAB matchup features No. 24 Louisville Cardinals (20-8 (14-2)) traveling to take on Clemson Tigers (20-8 (11-3)) at Littlejohn Coliseum, Clemson, SC. The Louisville hold a clear statistical edge this season, outperforming the Clemson by 5.5 points per game in scoring margin. That differential will be a key factor in this matchup.
On offense, Clemson averages 74.5 points per game, which exceeds what the Louisville defense typically allows (72.0 PPG). That mismatch could give the home side opportunities to exploit. The Louisville offense puts up 86.4 PPG and faces a Clemson defense allowing 65.6 PPG. The visitors have the offensive firepower to stay in this one.
Home court advantage is worth approximately 3.5 points in NCAAB, and Clemson will look to leverage their home crowd. Our model projects Clemson to win by approximately 4.1 points. The 68% confidence interval ranges from Clemson winning by 17 to losing by 9.
The market has this game at +1.5, but our model sees value on Clemson with a 5.6-point edge. Our line: Clemson -4.1. Combined with the total projection of 161 versus the market line of 146.5, there are opportunities to find value on both sides of this matchup.
Team Comparison
LOU Louisville
Stat
CLEM Clemson
20-8 (14-2)
Record
20-8 (11-3)
Last 10
86.4
PPG
74.5
72.0
Opp PPG
65.6
Current Odds
| Team | Moneyline | Spread | Total |
|---|---|---|---|
| LOU Louisville Cardinals | -130 | -1.5 | O 146.5 |
| CLEM Clemson Tigers | +110 | +1.5 | U 146.5 |
Source: Draft Kings Updated: Feb 28, 5:03 AM
Opening line: +1.5 / O/U 146.5
Model Projection
| Team | Moneyline | Spread | Total |
|---|---|---|---|
| LOU Louisville Cardinals | +108 | +4.1 | O 160.9 |
| CLEM Clemson Tigers | -108 | -4.1 | U 160.9 |
Source: Model Updated: Feb 28, 5:43 AM
Our Picks
Spread
Clemson (opened at +1.5)
56% Confidence
Play to -4.8
Total
Over (opened at 146.5)
78% Confidence
Play to 160.1
Recent Trends
Clemson has been one of the more consistent teams this season with a 20-8 (11-3) record. Their 20-win campaign speaks to the quality of play they've maintained throughout the year. They've been solid on both ends of the floor and will look to continue that form in front of their home fans.
Louisville comes in with an impressive 20-8 (14-2) record. They've been among the best teams in their conference and are playing with the confidence of a squad that expects to win. Road games can be tricky, but this team has the poise to handle hostile environments.
When these teams meet, the home team typically has the edge given the crowd advantage and familiarity factor. The team that controls tempo and limits turnovers will likely dictate the outcome of this matchup.
Matchup Edges
Clemson
Advantages
- Strong 20-8 (11-3) overall record this season
- Home court advantage and crowd support
- Elite defense allowing just 65.6 PPG
Disadvantages
- Potential for inconsistency in key moments
Louisville
Advantages
- Strong 20-8 (14-2) overall record this season
- Potent offense averaging 86.4 PPG
- Ranked #24 nationally — proven quality
Disadvantages
- Playing on the road without home crowd support
- Road fatigue and travel can impact energy levels