St. Louis Cardinals vs Cincinnati Reds
Friday, May 22, 2026
Matchup Analysis
This MLB matchup features St. Louis Cardinals (28-21 (13-13)) traveling to take on Cincinnati Reds (26-24 (13-11)) at Great American Ball Park, Cincinnati, Ohio. These two teams are closely matched, with both squads posting similar scoring differentials this season. This projects as a competitive contest that could go either way.
The offensive edge belongs to Reds at 5.0 PPG, a number that sits well above the 4.6 PPG the Cardinals defense allows. Look for the home team to push the pace and attack early. Meanwhile, Cardinals scores 4.5 PPG but faces a Reds defense that limits opponents to 5.0 PPG. The home team's defensive effort could be the difference-maker. Interestingly, neither offense has a clear statistical advantage over the opposing defense. This scoring equilibrium points to a game decided by execution in the final minutes.
In MLB, home court is valued at approximately 3.0 points. Reds will try to feed off that home atmosphere and put early pressure on the visitors. Reds is favored by 3.4 points in our projection, a margin that could go either way depending on game flow and shooting. This projects as a grind-it-out affair, with both teams averaging around 5 PPG in typical game environments. Low-scoring games compress margins and make covering large spreads harder.
This is one of those games where the oddsmakers have it dialed in. Our model sees no significant spread edge, but secondary markets like the total could still offer a narrow window of value.
Team Comparison
STL Cardinals
Stat
CIN Reds
28-21 (13-13)
Record
26-24 (13-11)
Last 10
4.5
PPG
5.0
4.6
Opp PPG
5.0
Current Odds
| Team | Moneyline | Spread | Total |
|---|---|---|---|
| STL St. Louis Cardinals | +104 ↑ | +1.5 | O 9.5 |
| CIN Cincinnati Reds | -126 ↓ | -1.5 | U 9.5 |
Source: DraftKings Updated: May 22, 4:31 PM
Opening line: -1.5 / O/U 9.5
Model Projection
| Team | Moneyline | Spread | Total |
|---|---|---|---|
| STL St. Louis Cardinals | +250 | +3.4 | O 9.5 |
| CIN Cincinnati Reds | -250 | -3.4 | U 9.5 |
Source: Model Updated: May 22, 5:07 AM
Our Picks
Spread
Pass
Model: -3.4 | Edge below threshold
Total
Pass
Model: 9.5 | Edge below threshold
Key Matchup Factors
**Key Matchup Factors:**
- Reds has a +0.0 scoring margin edge
- Home court advantage adds 3.5 points for Reds
- Expected scoring: Reds ~5, Cardinals ~5 (total ~10)
Recent Trends
Reds enters at 26-24 (13-11), hovering around the .500 mark. They've shown flashes of strong play but haven't been able to sustain consistency.
At 28-21 (13-13), Cardinals has been a middle-of-the-pack team with both impressive wins and puzzling losses.
In this head-to-head, execution will be paramount. The team that takes care of the basketball and wins the turnover battle will put itself in the best position to come out on top.
Matchup Edges
Reds
Advantages
- Home field advantage worth 3.0 runs in our model
- Elite pitching allowing just 5.0 RPG
- Net scoring margin of +0.0 RPG per game
Disadvantages
- Limited offense averaging just 5.0 RPG
- Allowing 5.0 RPG on defense leaves room for opponent scoring
- Opponent still holds a 29% model win probability
Cardinals
Advantages
- Stout pitching allowing just 4.6 RPG
- Net scoring margin of -0.0 RPG per game
- Model-projected win probability of 29%
Disadvantages
- Playing on the road, sacrificing 3.0 run of home field advantage
- Anemic offense at just 4.5 RPG limits scoring ceiling
- Model win probability of just 29% on the road